Hydroxypinacolone Retinoate
Hydroxypinacolone Retinoate
Also known as: HPR · Granactive Retinoid · Retinoate Ester
Anti-agingBrightening
“A next-generation retinoid that works without the irritation of retinol.”
What it does
Hydroxypinacolone retinoate (HPR) is a retinoic acid ester that binds directly to retinoid receptors in the skin — unlike retinol, which must be converted through multiple steps. This means it is more efficient and significantly less irritating than equivalent retinol concentrations. Increasingly used in products marketed as "gentle retinoid" alternatives.
Benefits
- Directly activates retinoid receptors — no conversion needed
- Anti-ageing: stimulates collagen, reduces fine lines
- Brightens skin tone and improves texture
- Significantly gentler than retinol at equivalent efficacy
- Suitable for retinol-sensitive skin types
How to layer
🌙 Evening routine
Cleanser
Toner
Serum
Moisturiser
Face Oil
After toning, before moisturiser
Good for
All skinSensitive skinNormal skinDry skin
Works well with
Avoid mixing with
Heads up
- ⚠Still causes photosensitivity — use at night and apply SPF
- ⚠Less research than retinol (fewer long-term studies)
How to use
Apply at night after cleansing. Start 2–3x per week and build up. Always follow with SPF in the morning.
Typical concentration: 0.01–0.1% in formulations